SIMULTANEOUS REPLACEMENTS OF TRIETHYL PHOSPHINE AND TETRAACETYL THIOGLUCOSE LIGANDS FROM AURANOFIN (AN ANTIARTHRITIC DRUG) WITH SELENOCYANATE 13C and 31P NMR STUDIES
| Autor: | Abdul Rahman Al Arfaj, Ahmad Saeed, Anvarhusein A. Isab, M. Naseem Akhtar |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Auranofin
Aqueous solution Stereochemistry chemistry.chemical_element Disproportionation Decomposition Medicinal chemistry Metal chemistry.chemical_compound chemistry visual_art Materials Chemistry visual_art.visual_art_medium medicine Methanol Physical and Theoretical Chemistry Selenium Phosphine medicine.drug |
| Zdroj: | Journal of Coordination Chemistry. 43:257-272 |
| ISSN: | 1029-0389 0095-8972 |
| DOI: | 10.1080/00958979808022674 |
| Popis: | The interaction of SeCN− with a new gold-based antiarthritic drug auranofin (Et3PAuSATg, where SATg− = 2, 3, 4, 6-tetra-O-acetyl-l-thio-β-D-glucopyranosato-S) in aqueous methanol has been studied by 13C and 31P NMR spectroscopy. It is observed that SeCN−releases bom ligands (i. e., SATg− and Et3P) to form [ATgS-Au-CN]− and [Et3P-Au-SeCN]. These newly generated species undergo further disproportionation and decomposition to generate species such as [(Et3P)2Au]+, [Au(CN)2]−, Et3PO and metallic selenium. The formation of [(Et3P)2Au]+ and [Au(CN)2]− is found to be much faster for Et3PAuNO3 than for Et3PAuSATg when reacted wim SeCN−. Exchange between unlabelled CN− of Au(CN)2 − and labelled Se13CN− was observed without selenium being precipitated from Se13CN−. |
| Databáze: | OpenAIRE |
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