IgE-sensitization profiles and lung function: a longitudinal study from childhood to early adulthood in the EGEA study
| Autor: | Jocelyne Just, Valérie Siroux, Christian Lupineck, Rudolf Valenta, Rachel Nadif, Isabelle Pin, Jean Bousquet, Anne Boudier |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
House dust mite
education.field_of_study Longitudinal study biology business.industry Population respiratory system medicine.disease biology.organism_classification Immunoglobulin E Latent class model respiratory tract diseases medicine.anatomical_structure Immunology medicine biology.protein Respiratory system education business Sensitization Asthma |
| Zdroj: | Epidemiology. |
| Popis: | Multiple sensitizations increases the risk for respiratory allergy, but studies investigating specific sensitization profiles are needed. We aimed to identify IgE-sensitization profiles to respiratory allergens and study their associations with lung function. IgE reactivity to microarrays allergens were measured twice using the MeDALL chip, in childhood and 11-years later in adult life, in 291 participants of the EGEA study. Latent class analysis (LCA) was performed at each point in time on IgE reactivity to 38 respiratory allergens. Cross-sectional associations between sensitization profiles and the level of FEV1 or FEF25-75 were estimated using linear mixed effect model (for repeated data) adjusted on age, sex and asthma. At baseline, the mean age of the population was 11 yrs, 52% ever had asthma and the mean(sd) of FEV1%pred was 97.1(12.6). The LCA identified 4 sensitization profiles, which were similar at both time points (frequencies): A "no/few IgE responses" (48%, 39%), B "IgE responses to pollen and pets allergens" (18%, 21%), C "IgE responses to some house dust mite allergens" (22%, 27%) and D "IgE responses to many aero-allergens" (12%, 13%). Subjects belonging to profiles C and D had lower FEF25-75 as compared to those belonging to profile A (p Using high resolution specific-IgE data in a well characterized population, we identified different sensitization profiles associated with lung function level. |
| Databáze: | OpenAIRE |
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