Immunohistochemical characterization of renal tumors in patients with Birt-Hogg-Dubé Syndrome

Autor:	Yoshiaki Imamura, Naoto Kuroda, Yukio Nakatani, Yoji Nagashima, Midori Ando, Masahiro Yao, Reiko Tanaka, Yasushi Nakamura, Akinobu Araki, Yasuhiro Iribe, Hiroko Gotoda, Mitsuko Furuya, Jun Matsushima, Fumi Kawakami
Rok vydání:	2015
Předmět:	Pathology medicine.medical_specialty Cell General Medicine Chromophobe cell Biology urologic and male genital diseases medicine.disease Birt–Hogg–Dubé syndrome female genital diseases and pregnancy complications Pathology and Forensic Medicine Germline mutation medicine.anatomical_structure medicine Immunohistochemistry Folliculin Clear cell Immunostaining
Zdroj:	Pathology International. 65:126-132
ISSN:	1320-5463
DOI:	10.1111/pin.12254
Popis:	Birt-Hogg-Dube syndrome (BHD) is an autosomal dominant disorder associated with a germline mutation of folliculin (FLCN). The affected families are at a high risk for developing multiple renal cell carcinomas (RCC). Little is known about the immunostaining patterns of mutant FLCN-associated RCCs. We investigated 32 RCCs obtained from 17 BHD patients. The studied tumors included chromophobe RCCs (n = 15), hybrid oncocytic/chromophobe tumors (HOCT) (n = 14) and clear cell RCCs (n = 3). Almost all chromophobe RCCs and HOCTs revealed positive staining for S100A1, Ksp-cadherin and CD82. They stained either focally or diffusely for CK7, and were negative for CA-IX. All clear cell RCCs were positively stained for CA-IX and negative for CK7. These data confirmed that mutant FLCN-associated oncocytic and clear cell RCCs exhibited generally similar immunostaining patterns compared to their sporadic counterparts. Frequent positive staining for S100A1, Ksp-cadherin and CD82 in chromophobe RCCs and HOCTs indicated that these two types were relatively similar rather than distinctively different in their patterns of immunoreactivity. Characteristic peri-nuclear halos and polygonal cells with clear cytoplasm, which often misleads pathologists into the diagnosis of clear cell RCC, should be carefully examined using an immunohistochemical panel including CA-IX, Ksp-cadherin, CD82 and CK7.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ad56f6123d8fa0be6472b0330d0e521f https://doi.org/10.1111/pin.12254 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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