Stereochemical Elucidation of the Pentacyclopropane Antifungal Agent FR-900848

Autor:	Anthony G. M. Barrett, W. W. Doubleday, K. Kasdorf, G. J. Tustin
Rok vydání:	1996
Předmět:	Antifungal chemistry.chemical_compound Natural product chemistry Streptoverticillium fervens Cyclopropanation Stereochemistry medicine.drug_class Organic Chemistry medicine Imidazolidines Nucleoside
Zdroj:	The Journal of Organic Chemistry. 61:3280-3288
ISSN:	1520-6904 0022-3263
DOI:	10.1021/jo960054k
Popis:	Full structural elucidation of FR-900848, an antifungal pentacyclopropane nucleoside natural product from Streptoverticillium fervens, is reported. A series of model compounds were prepared using multiple asymmetric Simmons−Smith cyclopropanation reactions. Comparisons of spectroscopic data of synthetic alkenes 9 and 10, quatercyclopropanes 11 and 12, and imidazolidines 13 and 14 with FR-900848 and its degradation products 2, 3, and 4 were consistent with the full structural assignment of the natural product as structure 7.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ad567e9034e08592f2c9c0ffbc243363 https://doi.org/10.1021/jo960054k Zobrazit plný text záznamu