FORMULATION AND EVALUATION OF CREAMS CONTAINING CELECOXIB INCLUSIONS FOR TREATING PSORIATIC ARTHRITIS

Autor:	Roopa Rani N, Shiva Pulla Reddy G, Padmini Iriventi, Sudharshan B
Rok vydání:	2020
Předmět:	Pharmacology medicine.medical_specialty business.industry food and beverages Pharmaceutical Science medicine.disease Dermatology Psoriatic arthritis Celecoxib medicine lipids (amino acids peptides and proteins) Pharmacology (medical) skin and connective tissue diseases business medicine.drug
Zdroj:	Asian Journal of Pharmaceutical and Clinical Research. :41-45
ISSN:	2455-3891 0974-2441
Popis:	Objective: The main objective of the present work was to prepare and evaluate creams of celecoxib inclusions which are nonsteroidal anti-inflammatory drug to treat psoriatic arthritis. Methods: Celecoxib inclusions were prepared using β-cyclodextrin to increase the solubility. These inclusions were incorporated in creams. Cocoa butter, triethanolamine, stearic acid, methylparaben, gum acacia, and coconut oil were used in cream preparation. Fourier transform infrared and differential scanning calorimetry studies were carried out for pure celecoxib and inclusions. Viscosity, pH, homogeneity, and type of emulsion under dye test were evaluation parameters done for creams. Results: All the results obtained were within the limits and confirmed increased solubility of celecoxib inclusions. Conclusion: From the results obtained, increase in solubility of celecoxib drug was confirmed by forming inclusions using β-CD as polymer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ad5631c3662f1ac20929ea6c3ff21da5 https://doi.org/10.22159/ajpcr.2020.v13i6.37469 Zobrazit plný text záznamu