| Autor: |
Phillip M. Hutchins, Colleen D. Lynch, Janie Maultsby |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
The Resistance Vasculature ISBN: 9781461267461 |
| DOI: |
10.1007/978-1-4612-0403-9_5 |
| Popis: |
This chapter will present the advantages and disadvantages of chronic in vivo preparations and describe the state of the art for some of these preparations. Investigations employing chronic in vivo techniques offer many advantages. For example, tumor necrosis factor alpha (TNFα) has been shown to inhibit the proliferation of endothelial cells in vitro, and to stimulate angiogenesis in vivo.1 The investigation of the interaction of all physiological systems is not possible with in vitro techniques. On the other hand, it is difficult to isolate individual systems and study precise mechanisms of action in vivo. Extrapolation of results acquired from in vivo studies to human medicine is also more appropriate. Knowing the in vivo effects of pharmacological interventions or physiological disturbances on undisturbed microvascular beds is a definite benefit to the interpretation of the true effect of the agent. Ideally, we need to know the response of all vascular beds to a particular perturbation. However, windows into the internal vascular beds (such as refinement of these techniques. Rapid progress is being made in telemetry methods for continuous monitoring of hemodynamic variables. Advancements in this area will also spill over into the telemetering of microvascular images. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
