Synthesis of H-3 labeled 5-fluoro-3-[3-[4-(5-methoxy-4-pyrimidinyl)-1-piperazinyl]propyl]-1H-indole, a serotonergic agent with potential antidepressant activity
| Autor: | Hiromi Morimoto, Lidia Doweykos, Bradley C. Pearce, Joseph P Yevich, Keith D. Combrink, Philip G. Williams, Douglas D. Dischino |
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| Rok vydání: | 1995 |
| Předmět: |
Indole test
Bicyclic molecule Stereochemistry medicine.drug_class Chemistry Organic Chemistry Carboxamide Serotonergic Biochemistry High-performance liquid chromatography Chemical synthesis Analytical Chemistry Drug Discovery Proton NMR medicine Radiology Nuclear Medicine and imaging Specific activity Spectroscopy |
| Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 36:789-794 |
| ISSN: | 0362-4803 |
| DOI: | 10.1002/jlcr.2580360810 |
| Popis: | The title compound was prepared by the LiAIT 4 reduction of 5-fluoro-3-[3-[4-(5-methoxy-4-pyrimidinyl)- 1-piperazinyl]-3-oxopropyl]- 1H-indole. The radiochemical purity of the product was 98.9% and the specific activity was calculated as 53.0 Ci/mmol from HPLC analyses and 55.6 Ci/mmol from 3 H NMR measurements. |
| Databáze: | OpenAIRE |
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