Multiplicity of cadmium binding sites in nucleotides: X-ray evidence for the involvement of O21′ and O3′ as well as phosphate and N7 in inosine 5′-monophosphate

Autor:	I. Jeeves, D.M.L. Goodgame, C.D. Reynolds, A.C. Skapski
Rok vydání:	1975
Předmět:	inorganic chemicals chemistry.chemical_classification Cadmium chemistry.chemical_element Crystal structure Biology Phosphate chemistry.chemical_compound Crystallography chemistry Biochemistry Ribose Genetics medicine Molecule Nucleotide Inosine Hypoxanthine medicine.drug
Zdroj:	Nucleic Acids Research. 2:1375-1380
ISSN:	1362-4962 0305-1048
DOI:	10.1093/nar/2.8.1375
Popis:	Single-crystal X-ray methods have been used to characterize a hydrated polymeric cadmium derivative of inosine 5'-monophosphate. In the structure there are two independent cadmium atoms, one of which binds to two ribose oxygen atoms, an N7 position on a base, and to three water molecules. The second metal atom binds to a phosphate oxygen, three water molecules, and to two N7 atoms, which are in cis-positions. For these last; the Cd-N bonds are appreciably out of the planes of the hypoxanthine bases so that the angle between these planes is only 31.4 degrees.
Databáze:	OpenAIRE
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