Domino donor lymphocyte infusion for secondary poor graft function after HLA‐mismatched allogeneic stem cell transplantation between HLA‐identical sibling pairs with congenital immunodeficiency
| Autor: | Koichi Nakanishi, Takeshi Yagi, Satoru Hamada, Nobuyuki Hyakuna, Shinobu Kiyuna, Tokiko Oshiro, Taichi Uehara, Shingo Kurokawa, Jiro Miyamoto |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Hyper IgM syndrome
business.industry Hematology Human leukocyte antigen medicine.disease Donor lymphocyte infusion Pathogenesis Transplantation 03 medical and health sciences 0302 clinical medicine Immune system Oncology 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Immunology medicine Sibling Stem cell business 030215 immunology |
| Zdroj: | Pediatric Blood & Cancer. 68 |
| ISSN: | 1545-5017 1545-5009 |
| DOI: | 10.1002/pbc.28851 |
| Popis: | Poor graft function (PGF) is a major obstacle to successful allogeneic stem cell transplantation after achieving normal bone marrow function. We report a successful treatment of domino DLI for poor graft function in younger brother with hyper IgM syndrome from HLA-identical elder brother with the same disorder with a history of HLA-mismatched unrelated bone marrow transplantation using same donor. Immunological profiling revealed that DLI-induced T-regulatory cells could correct skewed immune responses in the BM microenvironment due to secondary PGF pathogenesis. Immunological tolerized domino DLI can be a new therapeutic option for secondary PGF in HLA-identical sibling pairs with congenital immunodeficiency. |
| Databáze: | OpenAIRE |
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