Impact of Euro-American sublineages of Mycobacterium tuberculosis on new infections among named contacts
| Autor: | Leah G. Jarlsberg, Jordan Rose, Jennifer Grinsdale, J. Y. Feng, Michael Ann Janes, Philip C. Hopewell, Julie Higashi, Dennis Osmond, Midori Kato-Maeda, Payam Nahid |
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| Rok vydání: | 2017 |
| Předmět: |
Pulmonary and Respiratory Medicine
Tuberculosis Lineage (genetic) biology business.industry Tuberculin New infection medicine.disease biology.organism_classification Excessive alcohol consumption Mycobacterium tuberculosis Infectious Diseases Immunology medicine business Generalized estimating equation |
| Zdroj: | The International Journal of Tuberculosis and Lung Disease. 21:509-516 |
| ISSN: | 1027-3719 |
| Popis: | BACKGROUND The impact of demographic, clinical, and bacterial factors on new infection by Euro-American lineage Mycobacterium tuberculosis among contacts of patients with tuberculosis (TB) has not been evaluated. OBJECTIVE To describe the risk factors for new infection by Euro-American M. tuberculosis sublineages in San Francisco, California. DESIGN We included contacts of patients with TB due to Euro-American M. tuberculosis. Sublineages were determined by large-sequence polymorphisms. We used tuberculin skin testing or QuantiFERON®-TB Gold In-Tube to identify contacts with new infection. Regression models with generalized estimating equations were used to determine the risk factors for new infection. RESULTS We included 1488 contacts from 134 patients with TB. There were 79 (5.3%) contacts with new infection. In adjusted analyses, contacts of patients with TB due to region of difference 219 M. tuberculosis sublineage were less likely to have new infection (OR 0.23, 95%CI 0.06-0.84) than those with other sublineages. Other risk factors for new infection were contacts exposed to more than one patient with TB, contacts exposed for 30 days, or contacts with a history of smoking or excessive alcohol consumption. CONCLUSIONS In addition to well-known exposure and clinical characteristics, bacterial characteristics independently contribute to the transmissibility of TB in San Francisco. |
| Databáze: | OpenAIRE |
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