Plastically bendable pregabalin multi-component systems with improved tabletability and compressibility
| Autor: | René R. E. Steendam, Mustafa Yousuf, Patrick J. Frawley, Patrick McArdle, Leila Keshavarz, Barbara E. Schaller, U. B. Rao Khandavilli |
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| Rok vydání: | 2020 |
| Předmět: |
Improved solubility
010405 organic chemistry Component (thermodynamics) Oxalic acid Pregabalin General Chemistry 010402 general chemistry Condensed Matter Physics 01 natural sciences 0104 chemical sciences chemistry.chemical_compound chemistry Chemical engineering Compressibility medicine Anhydrous General Materials Science Salicylic acid medicine.drug |
| Zdroj: | CrystEngComm. 22:412-415 |
| ISSN: | 1466-8033 |
| Popis: | Pregabalin is an anti-convulsant blockbuster chiral drug with the trade name Lyrica in its S-form. Anhydrous pregabalin (SPG) is brittle in nature and herein, we report two novel plastically bendable SPG salts with pharmaceutically acceptable coformers oxalic acid and salicylic acid. These mechanically flexible salts show improved solubility, tabletability and compressibility compared to the marketed anhydrous form. |
| Databáze: | OpenAIRE |
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