H/D-exchange reactions with hydride-activated catalysts

Autor:	Volker Derdau, Jens Atzrodt, Wolfgang Holla
Rok vydání:	2007
Předmět:	Hydride Organic Chemistry chemistry.chemical_element Heterogeneous catalysis Biochemistry Chemical synthesis Analytical Chemistry Rhodium Catalysis chemistry Deuterium Transition metal Drug Discovery Organic chemistry Radiology Nuclear Medicine and imaging Spectroscopy Palladium
Zdroj:	Journal of Labelled Compounds and Radiopharmaceuticals. 50:295-299
ISSN:	1099-1344 0362-4803
Popis:	A safe, user friendly and efficient method to provide high deuterium incorporation into a variety of organic substrates was developed. Systematic screening of catalysts and activators revealed that the activation of the Pd- or Rh-catalyst by NaBD 4 is essential for the H/D exchange. The feasibility has been demonstrated by the successful application of this method to bi- and tricyclic aromatic compounds as well as chiral natural products like dextrorphan or drugs like formoterol.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ad2a4968b77a1417ff0760651db33e23 https://doi.org/10.1002/jlcr.1209 Zobrazit plný text záznamu Plný text