Synthesis and Immunostimulating Activity of Cysteine-Containing Derivatives of Glycyrrhizic Acid

Autor:	R. M. Kondratenko, L. A. Baltina, E. V. Vasil'eva, L. A. Baltina, Jr., A. F. Ismagilova, Kh. M. Nasyrov, N. Zh. Baschenko, R. M. Kireeva, S. M. Fridman, G. A. Tolstikov
Rok vydání:	2004
Předmět:	chemistry.chemical_compound Dipeptide chemistry Stereochemistry Reagent Primary immune response Organic Chemistry Molecule Bioorganic chemistry Carbohydrate Biochemistry Glycopeptide Cysteine
Zdroj:	Russian Journal of Bioorganic Chemistry. 30:53-59
ISSN:	1068-1620
Popis:	New cysteine-containing derivatives of glycyrrhizic acid were synthesized by its coupling with Cys(Bzl) esters or the Cys(Bzl)-Val-OBu t dipeptide by the active ester method (DCC/HOSu) or by Woodward's reagent K. The derivatives with Cys(Bzl) and Cys(Bzl)-Val residues attached to the carbohydrate part of the molecule stimulated the primary immune response and the reaction of delayed-Type hypersensitivity in mice at a dose of 2 mg/kg.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ad288746a4907a5c23830d44f722f231 https://doi.org/10.1023/b:rubi.0000015774.09619.80 Zobrazit plný text záznamu Full text from SpringerLink