Hyperbaric oxygen for radiation-induced cystitis: A long-term follow-up

Autor: R. Prisco, André Cardoso, D. Pereira, Carlos Ferreira, Manuel Cerqueira, R. Catarino, Frederico Carmo Reis, Tiago Correia, O. Camacho
Rok vydání: 2020
Předmět:
Zdroj: Actas Urológicas Españolas (English Edition). 44:561-567
ISSN: 2173-5786
DOI: 10.1016/j.acuroe.2020.03.004
Popis: Introduction and objectives Bladder complications may be seen in up to 12% of patients treated with pelvic irradiation. Hyperbaric oxygen therapy (HBOT) is an option for the management of radiation-induced hemorrhagic cystitis (RIHC). The aim of this study was to evaluate the efficacy of HBOT in radiation cystitis and to identify the predictive factors for a successful outcome. Material and Methods We retrospectively reviewed 105 patients diagnosed with RIHC which were treated with HBOT between 2007 and 2016 in our institution. Patients received 100% oxygen in a multiplace hyperbaric chamber at 2.4 atm for 80 min. All patients fulfilled a questionnaire documenting symptom severity pre-HBOT and at the end of the follow-up period. Results After a median of 40 HBOT sessions, there was success rate of 92,4% in the control of hematuria. During our follow-up period (median of 63 months) 24,7% patients presented with recurrence of hematuria. The mean score of the questionnaire-assessed variables: dysuria, urinary frequency and hematuria, was significantly lower after the follow-up period (p Our data shows that the sooner HBOT is delivered after the first episode of hematuria, better response rates are achieved and lower recurrences concerning hematuria were registered (p Conclusions Our results support the safety and long-term benefits of HBOT on RIHC and other distressful bladder symptoms, which represents an expected improvement of quality of life in our patients
Databáze: OpenAIRE
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