Co2(CO)8 as a Solid CO (g) Source for the Amino Carbonylation of (Hetero)aryl Halides with Highly Deactivated (Hetero)arylamines

Autor:	Kanchugarkoppal S. Rangappa, Ayyiliath M. Sajith, Srinivas Cheruku, Yatheesh Narayana, Sandhya C. Nagarakere, Kunigal S. Sagar, Kempegowda Mantelingu, Poornima Shetty, Kumara N Manikyanally
Rok vydání:	2021
Předmět:	Steric effects 010405 organic chemistry Chemistry Aryl Organic Chemistry Halide 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Catalysis Reaction rate chemistry.chemical_compound Bimetallic strip Carbonylation
Zdroj:	The Journal of Organic Chemistry. 86:5530-5537
ISSN:	1520-6904 0022-3263
Popis:	Carbonylation of (hetero)aryl iodides/bromides with highly deactivated 2-aminopyridines using Pd-Co(CO)4 bimetallic catalysis is accomplished. The use of Co2(CO)8 as a solid CO(g) source enhanced reaction rates observed when compared to CO(g), and excellent yields highlight the versatility of the developed protocol. A wide range of electronically and sterically demanding heterocyclic amines and (hetero)aryl iodides/bromides employed for this study resulted in excellent yields of amino carbonylated products. The developed methodology was further extended to synthesize Trypanosome brucie and luciferase inhibitors.
Databáze:	OpenAIRE
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