Effect of elevated BMI on radiation toxicity in early stage breast cancer patients
| Autor: | K. Nowak, Christopher Wright, Meredith Larose, Jordan Silberg, Nicole L. Simone |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty business.industry medicine.medical_treatment Cancer Retrospective cohort study Overweight medicine.disease Breast Conservation Treatment Radiation therapy Breast cancer Quality of life Internal medicine medicine Stage (cooking) medicine.symptom business |
| Zdroj: | Journal of Clinical Oncology. 34:1049-1049 |
| ISSN: | 1527-7755 0732-183X |
| DOI: | 10.1200/jco.2016.34.15_suppl.1049 |
| Popis: | 1049Background: Weight gain is associated with an increased risk of cancer and unfavorable outcomes after a cancer diagnosis. Women with an elevated body mass index (BMI) at diagnosis have worse quality of life after completing radiation therapy (RT) for breast cancer as well as increased recurrence rates and cancer-related death. In this retrospective study we investigated the impact of a patient’s BMI on RT acute toxicities and on recurrence rates in patients treated for early stage breast cancer. Methods: Charts of 397 consecutive patients with early stage breast cancer undergoing breast conservation treatment between 2008 and 2013 were retrospectively analyzed. Patients were divided into three groups, normal BMI, overweight (BMI 25-30 kg/m2) and obese (BMI > 30 kg/m2). Acute toxicities, including skin toxicity and fatigue, were scored using CTCAE version 4.0. Recurrence was assessed based on the patient’s last mammogram. The three patient groups were compared using ANOVA and a paired-test. Results: 42... |
| Databáze: | OpenAIRE |
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