Evaluation of the elemental, nutritional and antioxidant properties of Cov-Pla herbal preparations
| Autor: | Ishaya Yohanna Longdet, Kennedy I. Amagon, Bukata B. Bukar, Jacob Adegboyega Kolawole, Ukpe Ajima, Ismaila Shittu, Kakjing D. Falang, Noel N. Wannang, Yusuf Amuda Agabi, James G. Damen, Richard Joseph Kutshik, Stephen Daniel Davou, Simji S. Gomerep |
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| Rok vydání: | 2020 |
| Předmět: |
Pharmacology
Acid digestion Carbohydrate content Antioxidant Coronavirus disease 2019 (COVID-19) 010405 organic chemistry Chemistry DPPH medicine.medical_treatment Pharmaceutical Science Heavy metals 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Elemental analysis medicine Herbal preparations Food science |
| Zdroj: | African Journal of Pharmacy and Pharmacology. 14:370-376 |
| ISSN: | 1996-0816 |
| DOI: | 10.5897/ajpp2020.5198 |
| Popis: | The outbreak of the Covid-19 pandemic has had a dramatic effect on human existence and still shows no sign of abating. Scientists worldwide are therefore working assiduously to get new drug treatments to help mitigate the crisis. Some of those efforts involve research to obtain Covid-19 treatments from natural sources. The present study is aimed at evaluating the elemental, nutritional and antioxidant properties of Cov-Pla1, Cov-Pla2, Cov-Pla3 and PlaBoost herbal preparations. Elemental analysis was carried out using AAS after acid digestion of the samples. Proximate analysis of the formulations was done using the official AOAC methods while the antioxidant assay was carried out using the DPPH free radical scavenging method. The results of the study showed that the concentration of the heavy metals in all the samples were within acceptable regulatory limits. Proximate analysis revealed that the suspensions had protein content between 1.52-1.68 % and carbohydrate content of 0.79 – 1.08 % with low content of fat, crude fibre and ash. The formulations were found to be free of microbial contamination and stable for thirty days. Antioxidant evaluation revealed that Cov-Pla3 had the strongest free radical scavenging capacity with IC50 of 27.29 µg/mL while PlaBoost had the least (IC50: 251 µg/mL). The result of the study indicates that the formulations are free of metallic and microbial contaminants. In addition, proximate analysis has established some diagnostic parameters which will aid future authentication and purity assessment of the formulations. The formulations were all found to possess considerable antioxidant activity which will provide collateral benefit in relieving oxidative stress associated with Covid-19 infection. Key words: Covid-19, heavy metals, trace elements, proximate analysis, antioxidant. |
| Databáze: | OpenAIRE |
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