Phytochemical Profiling of Various Extracts of Glycine max (L.) Seeds and In-silico Approach for Hepato-Protective Activity
| Autor: | Vishnupriya S, Kowsalya S |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of Natural Remedies. :607-616 |
| ISSN: | 2320-3358 0972-5547 |
| DOI: | 10.18311/jnr/2022/29021 |
| Popis: | Cirrhosis and fibrosis are mainly characterized by the frequent and repeated inflammation of the renal cells. These renal disorders may also lead to hepatocarcinoma and even death, so we are in need of complementary and alternative medicine to treat renal diseases. The Soybean (Glycine max (L.) Merr.) seed is reported to have medicinal properties and pharmacological activities like anti-inflammatory and anti-oxidant. Here, we have evaluated various extracts (Water, Ethanol, Methanol, Hexane and Benzene) of Glycine max (L.) to predict their phytoconstituents and found that methanolic extract has more phytoconstituents. The finest chemicals in the methanolic extract, such as 3-Methoxy-hexane-1,6- diol, Choline, 9,12,15-Octadecatrien-1-ol, and tetradecane, were docked against Transforming Growth Factor-(TGF-β) a cytokine, transcription factors such as Peroxisome Proliferator-Activated Receptor (PPAR) and Pregnene X Receptor (PXR), and Nuclear Factor kappa-b (NF-KB) a protein complex. Comparatively, Choline shows higher negative binding energies against all the receptors and possesses hepato-protective activity. |
| Databáze: | OpenAIRE |
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