Piperazines

Autor: H. W. Stewart, N. Q. Quinones, K. L. Howard, E. A. Conroy, J. J. Denton
Rok vydání: 1954
Předmět:
Zdroj: Journal of the American Pharmaceutical Association (Scientific ed.). 43:625-628
ISSN: 0095-9553
DOI: 10.1002/jps.3030431016
Popis: The preparation and anticonvulsant activity of twenty-four new l-heterocyclic-4-substituted carbamyl- and -thiocarbamylpiperazines are presented. Three were prepared by the reaction of 1-diethylcarbamylpiperazine with the appropriate halogen-substituted heterocycle, while the remaining twenty-one were prepared by the reaction of 1-heterocyclic piperazioes with the appropriate isocyanate, isothiocyanate, or substituted carbamyl chloride. Five of these compounds received maximum anticonvulsant rating by the general testing methods employed.
Databáze: OpenAIRE