| Autor: |
Shuai Yuan, Michael G Levin, Olga E Titova, Jie Chen, Yuhao Sun, Veterans Affairs Million Veteran Program, Agneta Åkesson, Xue Li, Scott M Damrauer, Susanna C Larsson |
| Rok vydání: |
2023 |
| Zdroj: |
European Heart Journal Open. 3 |
| ISSN: |
2752-4191 |
| DOI: |
10.1093/ehjopen/oead008 |
| Popis: |
Aims Sleep duration has been associated with cardiovascular disease, however the effect of sleep on peripheral artery disease (PAD) specifically remains unestablished. We conducted observational and Mendelian randomization (MR) analyses to assess the associations of sleep duration and daytime napping with PAD risk. Methods and results Sleep traits were assessed for associations with incident PAD using cohort analysis among 53 416 Swedish adults. Replicated was sought in a case-control study of 28 123 PAD cases and 128 459 controls from the veterans affairs Million Veteran Program (MVP) and a cohort study of 452 028 individuals from the UK Biobank study (UKB). Two-sample Mendelian randomization (MR) was used for casual inference-based analyses of sleep-related traits and PAD (31 307 PAD cases 211 753 controls). Observational analyses demonstrated a U-shaped association between sleep duration and PAD risk. In Swedish adults, incident PAD risk was higher in those with short sleep [ Conclusion Short sleep duration was associated with an increased risk of PAD. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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