Molecular allergy diagnostics refine characterization of children sensitized to dog dander
| Autor: | Hans Grönlund, Ulrika Käck, Magnus P. Borres, Marianne van Hage, Jon R Konradsen, Anna Asarnoj, Gunnar Lilja |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Allergy medicine.medical_treatment Immunology Immunoglobulin E medicine.disease_cause Nasal provocation test 03 medical and health sciences 0302 clinical medicine Allergen medicine Immunology and Allergy Risk factor Sensitization Asthma biology business.industry fungi food and beverages Odds ratio medicine.disease 030104 developmental biology medicine.anatomical_structure 030228 respiratory system biology.protein business |
| Zdroj: | Journal of Allergy and Clinical Immunology. 142:1113-1120.e9 |
| ISSN: | 0091-6749 |
| Popis: | Background Sensitization to dog dander is an important risk factor for rhinoconjunctivitis and asthma but is not sufficient for diagnosing dog allergy. Molecular allergy diagnostics offer new opportunities for refined characterization. Objectives We sought to study the association between sensitization to all presently known dog allergen components and clinical symptoms of dog allergy in children evaluated by using nasal provocation tests (NPTs). Methods Sixty children (age, 10-18 years) sensitized to dog dander extract underwent NPTs with dog dander extract. Measurement of IgE levels to dog dander and to Can f 1, Can f 2, Can f 3, and Can f 5 was performed with ImmunoCAP, and measurement of IgE levels to Can f 4 and Can f 6 was performed with streptavidin ImmunoCAP. An IgE level of 0.1 kUA/L or greater was considered positive. Results There was an association between sensitization to an increasing number of dog allergen components and a positive nasal challenge result (P = .01). Sensitization to lipocalins (odds ratio [OR], 6.0; 95% CI, 1.04-34.5), in particular Can f 4 (OR, 6.80; 95% CI 1.84-25.2) and Can f 6 (OR, 5.69; 95% CI, 1.59-20.8), was associated with a positive NPT result. Monosensitization to Can f 5 was related to a negative NPT result (OR, 5.78; 95% CI, 1.01-33.0). Conclusion Sensitization to an increasing number of dog allergen components and to lipocalins is associated with dog allergy. Monosensitization to Can f 5 should not be regarded primarily as a marker for dog allergy. |
| Databáze: | OpenAIRE |
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