Synthesis and cytotoxicity of novel γ-piperidone-containing dibenzo-1,7-diaza-14-crown-4 ethers

Autor:	Hieu H. Truong, Duc M. Luong, Anatoly T. Soldatenkov, Anh T. Le, Nhung T. Dao, Victor N. Khrustalev, Dat T. Nguyen, Dat T. Le, Thuyen T. Do, Van T. T. Tran, Linh M. Nguyen
Rok vydání:	2019
Předmět:	010405 organic chemistry General Chemistry Crystal structure 010402 general chemistry 01 natural sciences Medicinal chemistry Crown Compounds In vitro 0104 chemical sciences chemistry.chemical_compound chemistry Moiety Cytotoxicity Ammonium acetate Human cancer
Zdroj:	Mendeleev Communications. 29:375-377
ISSN:	0959-9436
Popis:	For the development of new antitumor agents, novel dibenzo-1,7-diaza-14-crown-4 ethers containing γ-piperidone moiety were synthesized by a domino condensation of new podands, ketones and ammonium acetate. The crystal structure of one Ts of them was studied by X-ray diffraction. Four crown compounds were evaluated in vitro for cytotoxic activity against 5 human cancer cell lines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::acddcd3de3f6975419aec91b15e5fc84 https://doi.org/10.1016/j.mencom.2019.07.004 Zobrazit plný text záznamu Full Text from ScienceDirect