UnyLinker dimer impurity characterization and process improvement
| Autor: | Lijian Chen, Joshua L. Brooks, Andrew A. Rodriguez, Phil Olsen |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
010405 organic chemistry
Chemistry Oligonucleotide Dimer Organic Chemistry Intermolecular force Process improvement Nanotechnology 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Characterization (materials science) chemistry.chemical_compound Impurity Drug Discovery |
| Zdroj: | Tetrahedron Letters. 58:1050-1052 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2017.01.101 |
| Popis: | Herein, we describe the isolation and characterization of a UnyLinker dimer which, if left uncontrolled, can become incorporated in oligonucleotide products. The dimer is formed as a result of an unusual intermolecular osmium-catalyzed etherification. We demonstrate that by simply replacing H2O2 as the co-oxidant with NMO, none of the UnyLinker dimer impurity is formed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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