Evolution and Application of an Automated Platform for the Development of Crystallization Processes

Autor:	Aaron S. Cote, Tseng-En Hu, George Zhou, Aaron Moment, Stephanie J. Yaung
Rok vydání:	2013
Předmět:	Supersaturation Materials science business.industry Feedback control Organic Chemistry Automation law.invention Chemometrics law Physical and Theoretical Chemistry Crystallization Process evaluation business Process engineering
Zdroj:	Organic Process Research & Development. 17:1320-1329
ISSN:	1520-586X 1083-6160
Popis:	An automated crystallization platform enabled by FTIR and FBRM in combination with automation and chemometrics has provided a versatile tool for efficient crystallization process development. This system allows users to perform a “walkup” operation for routine process evaluation and also execute automated feedback control of crystallization based on a preset supersaturation profile via cooling and/or antisolvent addition. The concept, procedure, and benefits of the PAT-enabled crystallization platform are presented in general terms and then illustrated through several case studies where feedback control is applied to cooling, antisolvent addition, and “fed batch” (hot batch solution charged to lower-temperature seed bed) crystallization.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::acdc26b464c92d91714551e45155c04a https://doi.org/10.1021/op400187h Zobrazit plný text záznamu