Possible mechanisms responsible for the effect of dimedrol on nonsynthetic biotransformation of xenobiotics in rat liver

Autor:	M. Ya. Akhalaya, L. I. Deev
Rok vydání:	1997
Předmět:	Cytochrome biology Chemistry General Medicine Metabolism Pharmacology General Biochemistry Genetics and Molecular Biology In vitro chemistry.chemical_compound Biochemistry Biotransformation Rat liver biology.protein Xenobiotic
Zdroj:	Bulletin of Experimental Biology and Medicine. 124:888-890
ISSN:	1573-8221 0007-4888
Popis:	The ability of dimedrol to inhibit o-demethylation of paranitroanisole, which in rat liver is catalyzed by cytochrome P-450, is demonstratedin vivo andin vitro. The affinity of dimedrol for cytochrome P-450 is higher than that of other xenobiotics. It is suggested that the effect of dimedrol on the metabolism of paranitroanisole and some other xenobiotics is realized during formation of the enzyme—substrate complexes between these substances and cytochrome P-450.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::acc69c2a4fbe175e6842e8a75c6bded7 https://doi.org/10.1007/bf02446993 Zobrazit plný text záznamu Full text from SpringerLink