| Autor: |
Pramod R. Saxena, Patrick P.A. Humphrey, Joël Bockaert, Rebecca Hills, Sleight Andrew, Rodrigo Andrade, Amy S. Butler, Bryan L. Roth, Graeme R. Martin, Frank D. Yocca, Stephen J. Peroutka, Manfred Göthert, Julie Hensler, Carlos M. Villalón, Katharine Herrick-Davis, Luc Maroteaux, Richard M. Eglen, Paul R. Hartig, Nicholas M. Barnes, M. Hamon, Theresa Branchek, Aline Dumuis, Klaus Peter Latté, Mark W. Hamblin, Trevor Sharp, Ewan J. Mylecharane, John F. Neumaier, René Hen, John A. Peters, Marlene L. Cohen, Derek N. Middlemiss, Gordon Baxter, Daniel Hoyer |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
IUPHAR/BPS Guide to Pharmacology CITE. 2019 |
| ISSN: |
2633-1020 |
| DOI: |
10.2218/gtopdb/f1/2019.4 |
| Popis: |
5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [194] and subsequently revised [176]) are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. The diversity of metabotropic 5-HT receptors is increased by alternative splicing that produces isoforms of the 5-HT2A (non-functional), 5-HT2C (non-functional), 5-HT4, 5-HT6 (non-functional) and 5-HT7 receptors. Unique amongst the GPCRs, RNA editing produces 5-HT2C receptor isoforms that differ in function, such as efficiency and specificity of coupling to Gq/11 and also pharmacology [40, 482]. Most 5-HT receptors (except 5-ht1e and 5-ht5b) play specific roles mediating functional responses in different tissues (reviewed by [463, 382]). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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