Cytochrome P450 2A6 whole-gene deletion (CYP2A6*4 ) polymorphism reduces risk of lung cancer: A meta-analysis
| Autor: | Muhammad H Azme, Mohd Shafik Abd Majid, Azmawati M Nawi, Fadzrul Hafiz Johani |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Health (social science) business.industry Confounding Public Health Environmental and Occupational Health Medicine (miscellaneous) Odds ratio Cochrane Library medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Meta-analysis Internal medicine medicine Observational study business CYP2A6 Lung cancer Carcinogen |
| Zdroj: | Tobacco Induced Diseases. 18 |
| ISSN: | 1617-9625 |
| DOI: | 10.18332/tid/122465 |
| Popis: | Introduction Lung cancer is the most commonly diagnosed cancer worldwide and is the leading cause of cancer death. Smoking is a major contributor to the pathogenesis of lung cancer. Cytochrome P450 2A6 (CYP2A6) is responsible for the metabolic activation of most tobacco carcinogens. CYP2A6 genetic polymorphism can cause variations in the human metabolism of xenobiotics. We performed this meta-analysis to determine the association between whole-gene CYP2A6 deletion polymorphism (CYP2A6*4) and lung cancer risk. Methods The PubMed, SAGE, Science Direct, the Cochrane Library and Ovid databases were searched for observational studies before October 2018. Methodological quality was assessed using the Newcastle-Ottawa Quality Assessment Scale (NOS). Results Nine case-control studies involving 4385 lung cancer cases and 4142 controls were included in the analysis. The random-effects model was used to combine results from individual studies. The pooled odds ratio was 0.39 (95% CI: 0.27-0.56). There was no heterogeneity across studies (χ2=2.49, p=0.96, I2=0%). Conclusions Current evidence from the case-control studies suggests that the CYP2A6 whole-gene deletion polymorphism decreases the risk of lung cancer. Further research is needed to identify any potential confounding factors that may impact this association. |
| Databáze: | OpenAIRE |
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