Urotensin-II receptor antagonism does not improve renal haemodynamics or function in rats with endotoxin-induced acute kidney injury
| Autor: | Elisabeth Grimberg, Gregor Guron, Nicoletta Nitescu |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Pharmacology
medicine.medical_specialty Mean arterial pressure Physiology business.industry Acute kidney injury Renal function Thiobutabarbital medicine.disease Filtration fraction Oxygen tension Endocrinology Physiology (medical) Internal medicine Renal blood flow medicine business Perfusion medicine.drug |
| Zdroj: | Clinical and Experimental Pharmacology and Physiology. 37:1170-1175 |
| ISSN: | 0305-1870 |
| DOI: | 10.1111/j.1440-1681.2010.05449.x |
| Popis: | Summary 1. Urotensin-II (U-II) is a vasoactive peptide that influences renal haemodynamics and kidney function. The aim of the present study was to examine the effects of the selective U-II receptor antagonist, urantide, on renal haemodynamics, oxygenation and function in endotoxaemic rats. 2. Endotoxaemia was induced in Sprague–Dawley rats by an intraperitoneal dose of lipopolysaccharide (LPS; Escherichia coli O127:B8, 7.5 mg/kg). At 16 h after endotoxin was given, renal clearance experiments were carried out in thiobutabarbital anaesthetized rats. Group 1, sham-saline; group 2, sham-urantide; group 3 LPS-saline; and group 4, LPS-urantide received isotonic saline or urantide (0.2 mg/kg bolus intravenously, followed by an infusion of 1.2 mg/kg/h throughout) after baseline measurements. Kidney function, renal blood flow (RBF), and cortical and outer medullary perfusion (laser-Doppler flowmetry) and oxygen tension (Clark-type microelectrodes) were analysed during 2 h of drug administration. 3. At baseline, endotoxaemic rats showed approximately 50% reductions in glomerular filtration rate (GFR) and RBF (P |
| Databáze: | OpenAIRE |
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