Synthesis, hypolipidemic and antifungal activity of tetrahydroberberrubine sulfonates
| Autor: | E. D. Shirokova, Tatyana G. Tolstikova, Nina I. Komarova, Olga A. Luzina, Roman A. Bredikhin, I. V. Nechepurenko, M. V. Khvostov, D. S. Fadeev, Alexander M. Maksimov, N. F. Salakhutdinova, T. S. Frolova, O. I. Sinitsyna |
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| Rok vydání: | 2019 |
| Předmět: |
Antifungal
Cryptococcus neoformans biology 010405 organic chemistry medicine.drug_class Chemistry Cholesterol General Chemistry Bromine atom 010402 general chemistry biology.organism_classification medicine.disease 01 natural sciences Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound Sulfonate Simvastatin Hyperlipidemia medicine medicine.drug |
| Zdroj: | Russian Chemical Bulletin. 68:1052-1060 |
| ISSN: | 1573-9171 1066-5285 |
| DOI: | 10.1007/s11172-019-2519-y |
| Popis: | The paper describes the synthesis of new tetrahydroberberrubine derivatives containing polyfl uorophenyl- or alkylsulfonate groups at the O(9) position as well as those containing or not containing a bromine atom at the C(12) position. In a model of acute Triton-induced hyperlipidemia, tetrahydroberberrubine 9-O-(heptafluoro-4’-toluene)sulfonate was shown to reduce the cholesterol level by 23.5%, which is comparable with the eff ect of Simvastatin. At a concentration of 32 μg mL−1, tetrahydroberberrubine 9-O-pentafluorobenzenesulfonate inhibits the growth of the fungus Cryptococcus neoformans by 81.3±3.5%. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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