Fatal interstitial pneumonitis following high-dose intermittent chlorambucil therapy for chronic lymphocytic leukemia

Autor:	Gerald Justh, Emmanuel C. Besa, Rosaline R. Joseph, Sally D. Lane
Rok vydání:	1981
Předmět:	Cancer Research Pathology medicine.medical_specialty Chlorambucil Respiratory distress business.industry Chronic lymphocytic leukemia Interstitial lung disease medicine.disease Oncology Prednisone Fibrosis hemic and lymphatic diseases Medicine business Complication medicine.drug Pneumonitis
Zdroj:	Cancer. 47:32-36
ISSN:	1097-0142 0008-543X
DOI:	10.1002/1097-0142(19810101)47:1<32::aid-cncr2820470107>3.0.co;2-q
Popis:	Interstitial lung disease has been reported in association with numerous alkylating agents and other chemotherapeutic drugs. Chlorambucil has only rarely been implicated in this complication. We report a case of a 74-year-old man with chronic lymphocytic leukemia who received high-dose intermittent chlorambucil and prednisone every two weeks. Following several of these courses of therapy, respiratory distress occurred 9 to 12 days after the chlorambucil was given. During the final episode, open lung biopsy was performed and demonstrated typical changes of drug-induced pneumonitis, with interstitial infiltrates and fibrosis and proliferation of type II alveolar lining cells.
Databáze:	OpenAIRE
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