ChemInform Abstract: Palladium-Catalyzed α-Arylation of Benzylic Phosphonates

Autor:	Patrick J. Walsh, Sonia Montel, Yuying He, Ludovic Raffier
Rok vydání:	2014
Předmět:	inorganic chemicals chemistry.chemical_compound chemistry organic chemicals Aryl chemistry.chemical_element heterocyclic compounds General Medicine Phosphonate Medicinal chemistry Catalysis Palladium
Zdroj:	ChemInform. 45
ISSN:	0931-7597
DOI:	10.1002/chin.201433199
Popis:	A new synthetic route to access diarylmethyl phosphonates is presented. The transformation enables the introduction of aromatic groups on benzylic phosphonates via a deprotonative cross-coupling process (DCCP). The Pd(OAc)2/CataCXium A-based catalyst afforded a reaction between benzyl diisopropyl phosphonate derivatives and aryl bromides in good to excellent isolated yields (64–92%).
Databáze:	OpenAIRE
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