Studies in marine cembranolide synthesis: A synthesis of 2,3,5-trisubstituted furan intermediates for lophotoxin and pukalide

Autor:	Bernard Joseph Banks, Gardner Mark, Ian Paterson
Rok vydání:	1989
Předmět:	Organic Chemistry chemistry.chemical_element Substrate (chemistry) Zinc Ring (chemistry) Biochemistry chemistry.chemical_compound chemistry Alcohol oxidation Furan Drug Discovery Lophotoxin Organic chemistry Tin Glycol cleavage
Zdroj:	Tetrahedron. 45:5283-5292
ISSN:	0040-4020
Popis:	Pd(0)-catalysed coupling between various furyl zinc or tin compounds and vinyl iodides is demonstrated to be a versatile method for the synthesis of 2,3-dialkyl-5-alkenylfurans like 3, as potential precursors of the ring system of lophotoxin and pukalide. A possible cyclisation substrate was successfully prepared by glycol cleavage, 21 → 24, when alcohol oxidation failed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ac9b029ffd983b0854276b3b9f4d22b2 https://doi.org/10.1016/s0040-4020(01)81102-9 Zobrazit plný text záznamu