Calves Chronically Implanted with a Total Artificial Heart as a Pharmacological Model
| Autor: | George M. Pantalos, White Rk, Goldenberg If, Robison Pd, Shaw Wj, Don B. Olsen, Landa Ms, James W. Long, Everett Sd |
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| Rok vydání: | 1991 |
| Předmět: |
Inotrope
medicine.medical_specialty 030232 urology & nephrology Biomedical Engineering Medicine (miscellaneous) Bioengineering 030204 cardiovascular system & hematology Cardiotonic Agents law.invention Biomaterials 03 medical and health sciences 0302 clinical medicine Afterload law Artificial heart Internal medicine Medicine business.industry General Medicine medicine.disease Surgery Preload medicine.anatomical_structure Epinephrine Heart failure Cardiology Vascular resistance business medicine.drug |
| Zdroj: | The International Journal of Artificial Organs. 14:775-780 |
| ISSN: | 1724-6040 0391-3988 |
| DOI: | 10.1177/039139889101401206 |
| Popis: | Pharmacological therapy for congestive heart failure includes drugs that have both inotropic and vasoactive effects, although it is sometimes difficult to differentiate between the two effects. An animal with an implanted total artificial heart (TAH) allows the investigation of the vascular effect of these drugs in the absence of the effect on the myocardium. An advantage of the TAH model is its sensitivity to changes in right and left ventricular preload and afterload. Four instrumented TAH calves were given vasoactive drugs and the response was compared to control. Epinephrine, dopamine, isoproterenol, and nitroprusside were selected because of the predictability of their responses. Epinephrine caused a significant increase in systemic vascular resistance (SVR), and dopamine caused a significant increase in Pulmonary vascular resistance (PVR) and Isoproterenol caused a significant decrease in PVR. TAH implanted calves can thus serve as a pharmacological model to study the vascular response, which may be useful in investigation of new agents with inotropic and vascular effects. |
| Databáze: | OpenAIRE |
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