High-risk squamous cell carcinoma of the ear - A potential role for sentinel node biopsy
| Autor: | Paula F. Wrafter, John Kelly, Padraic J. Regan, Suzanne M. Beecher, Cormac W. Joyce |
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| Rok vydání: | 2017 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.diagnostic_test business.industry Lymphovascular invasion Cartilage Sentinel lymph node Sentinel node medicine.disease Nodal disease Metastasis stomatognathic diseases 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Internal medicine Biopsy medicine Basal cell business |
| Zdroj: | Head & Neck. 39:1840-1844 |
| ISSN: | 1043-3074 |
| Popis: | Background Squamous cell carcinomas (SCCs) of the external ear have a significant rate of metastasis. The purpose of this study was to present analyzed factors associated with auricular SCC metastasis in order to identify a group that may benefit from sentinel lymph node biopsy (SLNB). Methods We performed a retrospective review of all operable SCCs between 2009 and 2014. The association between high-risk features and metastasis were analyzed. Results One hundred eighty-nine auricular SCCs were excised. Local recurrence was noted in 11% and 9.5% developed metastases. Cartilage, perineural, and lymphovascular invasion were significantly associated with metastasis, as were increased tumor depth and diameter (P < .001). All patients with metastasis developed nodal disease. Conclusion Factors, including poor differentiation, perineural, cartilage, and lymphovascular invasion, are associated with auricular SCC metastasis. Patients with 2 or more high-risk features may benefit from SLNB in order to identify and treat early nodal disease and possibly reduce the risk of further spread. |
| Databáze: | OpenAIRE |
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