A pH-sensitive excited state intramolecular proton transfer fluorescent probe for imaging mitochondria and Helicobacter pylori
| Autor: | Kyeong Im Hong, Seong Min Lee, Woo Dong Jang, Seong Hyun Park, Injae Shin |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Excited state intramolecular proton transfer
02 engineering and technology Mitochondrion 010402 general chemistry Photochemistry 01 natural sciences chemistry.chemical_compound symbols.namesake pH indicator Stokes shift Materials Chemistry Electrical and Electronic Engineering Instrumentation Dual emission Metals and Alloys Compartment (chemistry) 021001 nanoscience & nanotechnology Condensed Matter Physics Fluorescence 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Benzothiazole chemistry symbols 0210 nano-technology |
| Zdroj: | Sensors and Actuators B: Chemical. 286:148-153 |
| ISSN: | 0925-4005 |
| Popis: | An hydroxythiophene-conjugated benzothiazole (T2(OH)B) was synthesized as a pH sensitive fluorescent probe. T2(OH)B displayed dual emission behavior due to the excited state intramolecular proton transfer (ESIPT) process, while the methoxy analogs, T2(OMe)B, did not. T2(OH)B showed strong fluorescence enhancement above physiological pHs. The applicability of T2(OH)B as a biological pH indicator was demonstrated by its use for staining mitochondrial compartment and H. pylori. Owing to its strong fluorescence emission with a large stokes shift and its effective response to pH, T2(OH)B serves as a platform for the design of new types of fluorescent probes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect