| Autor: |
Xiao-guang Zhou, Jing-jing pan, yang yang, xiao-qing chen, jie shao, lei wang, Mei-ling Tong |
| Rok vydání: |
2022 |
| DOI: |
10.21203/rs.3.rs-1517853/v1 |
| Popis: |
Objective: As one kind of novel non-coding RNA with high stability and conservatism, circular RNAs (circRNAs) are involved in different biological processes. Although growing evidence has supported the important role of circRNAs in renal diseases, the specific mechanism still remains unknown in neonatal acute kidney injury (AKI).Methods: High throughput sequencing analysis was applied to investigate the expression patterns of circRNAs in the comparison between hypoxia induced AKI neonates and controls. Then, bioinformatics analysis was conducted to predict the function of differentially expressed circRNAs and construct the network of circRNA-miRNA interaction. Finally, the differentially expressed circRNAs were further screened and determined by quantitative real-time PCR. Results: (1) We identified 296 differentially expressed circRNAs (circRNAs with Fold change > 2 and P value Conclusion: This study could contribute to future research of circRNAs in the pathogenesis of neonatal AKI and facilitate the identification of novel therapeutic targets of circRNAs. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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