New aspects of the chemistry of 2,3-dihydro-1H-1,5-benzodiazepine

Autor:	Valeriy D. Orlov, F. G. Yaremenko, Nadezhda N. Kolos, V. F. Lavrushin
Rok vydání:	1980
Předmět:	Benzodiazepine Primary (chemistry) Chemistry Stereochemistry medicine.drug_class Organic Chemistry Condensation Medicinal chemistry Cinnamaldehyde Adduct Catalysis chemistry.chemical_compound Intramolecular force medicine
Zdroj:	Chemistry of Heterocyclic Compounds. 16:547-550
ISSN:	1573-8353 0009-3122
DOI:	10.1007/bf00561358
Popis:	Under basic catalysis conditions the reaction of 4- and 4'-substituted chalcones with o-phenylenediamine leads to 2,3-dihydro-2,4-diaryl-1H-1,5-benzodiazepines; β-amino adducts, the ability of which to undergo intramolecular condensation increases as the basicity of the catalyst is increased, are formed as intermediates. A different pathway for the process (the formation of an azomethine) is observed in the reaction with cinnamaldehyde. It is concluded that conformational factors play a primary role in the direction of the reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ac85f2bdb3053a20eef3458fd7410a10 https://doi.org/10.1007/bf00561358 Zobrazit plný text záznamu Full text from SpringerLink