Natural product-derived building blocks for combinatorial synthesis. Part 1. Fragmentation of natural products from myxobacteria

Autor:	Jutta Niggemann, Ronald Frank, Norbert Zander, Gerhard Höfle, Katrin Michaelis
Rok vydání:	2002
Předmět:	chemistry.chemical_classification Natural product biology Carboxylic acid Fragmentation (computing) Spot synthesis Structural diversity Primary alcohol biology.organism_classification Combinatorial synthesis Combinatorial chemistry chemistry.chemical_compound chemistry Myxobacteria
Zdroj:	J. Chem. Soc., Perkin Trans. 1. :2490-2503
ISSN:	1364-5463 1472-7781
Popis:	Novel and unique chiral building blocks of high structural diversity were obtained by selective chemical fragmentation of natural products from myxobacteria. Subsequent modification reactions provided primary alcohol and carboxylic acid derivatives, which are suitable for the construction of combinatorial chemical libraries. The single SPOT synthesis of a hybrid structure on a polypropylene membrane was employed to demonstrate the chemical recombination of such rare building blocks on a micro-scale.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ac83dc5888369138369232e76c383b50 https://doi.org/10.1039/b206953a Zobrazit plný text záznamu