Necrotizing Vasculitis at Granulocyte-Macrophage-Colony-Stimulating Factor Injection Sites
| Autor: | Razelle Kurzrock, Madeleine Duvic, Jordan U. Gutterman, Kathryn L. Farmer |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Chemotherapy
Pathology medicine.medical_specialty Erythema business.industry medicine.medical_treatment Dermatology General Medicine Neutropenia medicine.disease Granulocyte macrophage colony-stimulating factor Necrotizing Vasculitis Immunology medicine Maculopapular rash Chills medicine.symptom Aplastic anemia business medicine.drug |
| Zdroj: | Archives of Dermatology. 126:1243 |
| ISSN: | 0003-987X |
| DOI: | 10.1001/archderm.1990.01670330123030 |
| Popis: | To the Editor.— Granulocyte-macrophage-colony-stimulating factor is a 14 to 35 kd glycoprotein cytokine produced by T cells, endothelial cells, and fibroblasts.1The granulocyte-macrophage-colony-stimulating factor has multiple biologic effects, including stimulation of multipotent colonies, maturation of granulocytes and monocytes, bacterial phagocytosis, and enhancement of antigen-presenting cells.1-3The granulocyte-macrophage-colony-stimulating Hemorrhagic bulla at granulocyte-macrophage-colony-stimulating factor injection site on the left thigh with surrounding erythematous livedo pattern. factor has been used in aplastic anemia, myelodysplastic syndrome, before and after chemotherapy for neutropenia secondary to the chemotherapy and with bone marrow transplantation, and in acquired immunodeficiency syndrome. The most commonly reported side effects include bone pain, fever, chills, myalgias, arthralgias, decreased appetite, and nausea. Additionally, of 23 patients with advanced malignancy treated with granulocyte-macrophage-colony-stimulating factor, nine had a cutaneous eruption4consisting of local erythema and pruritus at the injection site, recall erythema at previous injection sites, or a generalized maculopapular rash. We report |
| Databáze: | OpenAIRE |
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