Phytochemical screening, antioxidant, anti-diabetic and cytotoxic activity of leaves of Pandanus canaranus Warb
| Autor: | Krishnan Vasanth, Venkatachalam Balamurugan, Kannan Raja, Subramaniam Selvakumar |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
010302 applied physics
Metal chelating activity Antioxidant Traditional medicine DPPH medicine.medical_treatment Ethyl acetate 02 engineering and technology 021001 nanoscience & nanotechnology 01 natural sciences Staining chemistry.chemical_compound chemistry Phytochemical 0103 physical sciences medicine DAPI 0210 nano-technology Cytotoxicity |
| Zdroj: | Materials Today: Proceedings. 48:322-329 |
| ISSN: | 2214-7853 |
| DOI: | 10.1016/j.matpr.2020.07.603 |
| Popis: | Pandanus, a traditional medicinal plant is used for the ailment of several diseases in India. The extract prepared from leaves was tested for its secondary metabolites and also to phenolics, alkaloids, saponins and flavonoids. Subsequently, the antioxidant activity was observed using DPPH, reducing power, FRAP, metal chelating activity and total antioxidant assays. It is evident that more secondary metabolites were present in ethyl acetate and methanol solvents enriched in free radicals scavenging ability compared with other solvents. Further, the extracts were tested and observed for potential presence of anti-diabetic activity with strong inhibition of α-amylase and α-glucosidase which suggests that the absorption and digestion of carbohydrates would possibly reduce the blood glucose levels and hence help management of type-2 diabetes. Though the ethyl acetate and methanol extract exhibited cytotoxicity and apoptosis activity on human HT-29 colon cancer cell line via MTT, AO/EtBr and DAPI staining assays that inhibits cancer cell line which in turn prevents cancer. |
| Databáze: | OpenAIRE |
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