CORRELATION OF FREE HEMOGLOBIN LEVEL AND PLASMA NITRIC OXIDE IN PACKED RED CELL DURING BLOOD BANK STORAGE PERIOD

Autor:	Ricca Fitria, Desywar Desywar, Zelly Dia Rofinda
Rok vydání:	2019
Předmět:	Red Cell business.industry Vasodilation Storage lesion Blood flow medicine.disease Hemolysis Nitric oxide Andrology chemistry.chemical_compound chemistry Free hemoglobin medicine General Earth and Planetary Sciences business Blood bank General Environmental Science
Zdroj:	INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY. 25:26-30
ISSN:	2477-4685 0854-4263
DOI:	10.24293/ijcpml.v25i1.1485
Popis:	Stored red blood cells undergo morphological and biochemical changes with increased storage time, commonly refferred as the storage lesion, reduced integrity of erythrocyte membrane, causing hemolysis and increased free plasma hemoglobin level. Nitric Oxide (NO) is an endogenous vasodilator with the major role in vascular and blood flow regulation. Accumulation of free hemoglobin (fHb) during storage RBC hemolysis is thought to be correlated with elevated NO consuming causes low NO level that significantly impair endothelial function. This study aim to was to analyze the correlation of free Hb and plasma nitric oxide level during PRC storage period in the blood bank. This research was an analytic study with a cross-sectional design to 14 unit PRC those were stored in Dr. M. Djamil Padang Hospital Blood Bank. The study was conducted from May 2016 to August 2017. The assay was performed for 28 days of storage with one week intervals. Free plasma hemoglobin and NO level were analyzed by cyanmethemoglobin and colorimetry method respectively. Spearman test was used to access the correlation between free Hb level and nitric oxide plasma with p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ac69a9fba655af4453aac3c1045f6ee5 https://doi.org/10.24293/ijcpml.v25i1.1485 Zobrazit plný text záznamu