| Popis: |
Organic brain disease is the result of neuronal and vascular injury that can occur as a consequence of several injury paradigms that include anoxia, vascular disease, and metabolic insults. Such insults can then subsequently precipitate both anatomic and cellular neuronal disease. However, it is the downstream cellular and molecular pathways that are increasingly being recognized as vital mechanisms that can both prevent and reverse neuronal injury. This article provides a pathophysiologic approach to the diagnosis and treatment of organic brain disease that incorporates current knowledge from both clinical patient studies and basic science investigations. Further analysis of neuronal injury that relies on a “bimodal” clinical and basic approach will foster the development of rationale, efficacious, and safe therapeutic interventions for the treatment of organic brain disease. |
