| Popis: |
The regulation of mammalian liver regeneration is complex. From both experimental animal studies and the use of isolated hepatocytes, numerous hormones, nutrients and growth factors have been implicated (Bucher and Strain, 1992). In keeping with all mammals, the human liver regenerates following resection or injury. More recently with the advent of liver transplantation, other situations where human liver growth occurs have also become pertinent. For example, organs from younger donors transplanted into larger, older recipients enlarge to the correct organ size for body weight (Van Thiel et al., 1987) and segmental grafts also regenerate with growth and development in pediatric recipients (Emond et al., 1989). The factors which control these responses in man are not well understood. |
