Systemic Sclerosis: New Insights in Autoimmunity

Autor:	E. M. G. J. De Jong, Henk E. Viëtor, Suzanne E. J. Kaal, F. H. J. Van Den Hoogen
Rok vydání:	1999
Předmět:	Pathogenesis business.industry Female patient Immunology Medicine Microchimerism Disease business medicine.disease_cause General Biochemistry Genetics and Molecular Biology Autoimmunity
Zdroj:	Proceedings of the Society for Experimental Biology and Medicine. 222:1-8
ISSN:	1525-1373 0037-9727
DOI:	10.1111/j.1525-1373.1999.09991.pp.x
Popis:	The strong female predilection of systemic sclerosis, especially in women after their childbearing years, and the clinical and histopathological similarities with chronic graft-versus-host disease make systemic sclerosis an interesting subject of debate. Recent studies concerning the pathogenesis of this disease demonstrated the persistence of fetal cells in the maternal circulation in a majority of female patients. How or whether microchimerism is involved in the pathogenesis of systemic sclerosis remains to be elucidated. The present paper reviews the recent findings on the subject.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ac59cbb5060f1b8efc1d6a3dc2ed5e15 https://doi.org/10.1111/j.1525-1373.1999.09991.pp.x Zobrazit plný text záznamu Plný text