| Autor: |
Secil AK AKSOY, Berrin TUNCA, Tuncay YILMAZLAR, Özgen IŞIK, Ersin ÖZTÜRK, Melis MUTLU, Çağla TEKİN, Baris GULCU, Nesrin UGRAS, Ömer YERCİ, Gülşah ÇEÇENER, Ünal EGELİ |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Online Türk Sağlık Bilimleri Dergisi. |
| ISSN: |
2459-1467 |
| Popis: |
Objective: We hypothesized that microRNAs (miRNAs) may be involved in tumor development by critically regulating cancer stem cell (CSC) markers in early stages of colon cancer (eCC). The aim of this study was to determine the expression profiles of miRNAs in CSC-positive eCC patients and to examine their associations with recurrence. Materials and Methods: We analyzed CD133, LGR5 and SOX2 expression profiles to determine CSC status in 30 eCC specimens. Then, using the results of RT2 miRNA PCR custom arrays, we evaluated the expression profiles of 38 miRNAs in CSC-positive eCC patients. Results: Recurrence occurred in 5 patients within 10 years after surgery. We determined down-regulation of miR-125b and up-regulation of miR-135b were significant in CSC-positive eCC patients (P= 0.021, P= 0.001, respectively). We found that low expression of miR-125b was associated with recurrence in eCC (P= 0.0022). Conclusion: We suggest that recurrence might be prevented by increasing expression of miR-125b in eCC. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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