Synthesis and Biological Evaluation of m-PEG Attached Acridinedione Derivatives as Antimicrobial, Antioxidant and Anticancer Agents

Autor:	Indira Viswambaran Asharani, Tathagata Dey
Rok vydání:	2021
Předmět:	Antioxidant 010405 organic chemistry Chemistry medicine.medical_treatment General Chemistry Antimicrobial 01 natural sciences 0104 chemical sciences 03 medical and health sciences 0302 clinical medicine Biochemistry 030220 oncology & carcinogenesis PEG ratio medicine Biological evaluation
Zdroj:	Asian Journal of Chemistry. 33:1603-1610
ISSN:	0975-427X 0970-7077
DOI:	10.14233/ajchem.2021.23241
Popis:	Among heterocycles, a wide variety of nitrogen heterocycles have been exploited to develop pharmaceutically important molecules. Particularly, acridines are clinically used potential drug candidates showing various pharmacological activities. Some of the novel m-PEG attached acridinediones 4(a-j) were synthesized with the readily available starting materials such as dimedone, glycine and aldehydes. Structures of the synthesized compounds were characterized by spectral techniques. The synthesized compounds (4a-j) were evaluated for in vitro antimicrobial, antioxidant and anticancer activities. Compounds 4d, 4e and 4g were found to produce potent antimicrobial activities against Gram-positive and Gram-negative organisms while 4c active against only Gram-positive organisms when compared with the standard, ciprofloxacin. On the other side, 4d and 4i produced potent antioxidant activity and 4a, 4d and 4g exhibited comparable anticancer properties.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ac585a5c9f389b5fcd57dfa4a60135a5 https://doi.org/10.14233/ajchem.2021.23241 Zobrazit plný text záznamu