A Domino Process for the Sustainable Synthesis of Quinazolin-4(3H)-ones with Direct Chemo- and Regioselective Bromination
| Autor: | Rozita Yazzaf, Mehdi Jahani, Mehdi Adib, Ehsan Sheikhi, Mehdi Ghavidel |
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| Rok vydání: | 2018 |
| Předmět: |
Primary (chemistry)
010405 organic chemistry Chemistry Organic Chemistry Regioselectivity Halogenation 010402 general chemistry Chloroacetyl chloride 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Sustainable construction Bromide Organic chemistry Domino process Quinazolinone |
| Zdroj: | Synlett. 29:2046-2050 |
| ISSN: | 1437-2096 0936-5214 |
| DOI: | 10.1055/s-0037-1610226 |
| Popis: | An efficient approach is reported for the direct and sustainable construction of quinazolin-4(3H)-ones through a three-component reaction of isatoic anhydride, primary amines, and bromoacetyl bromide or chloroacetyl chloride in the presence of K2CO3 in DMSO. With bromoacetyl bromide, mono- or dibrominated quinazolinone scaffolds were obtainable in a chemo- and regioselective manner. |
| Databáze: | OpenAIRE |
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