BRAF Mutation Status Concordance Between Primary Cutaneous Melanomas and Corresponding Metastases: A Review of the Latest Evidence
| Autor: | Á. Santos-Briz, M. Yuste-Chaves, E. Godoy-Gijón |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Pathology Histology Concordance medicine.medical_treatment Dermatology Pathology and Forensic Medicine Metastasis Targeted therapy 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Turning point neoplasms business.industry Melanoma Cancer medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis Mutation (genetic algorithm) Cutaneous melanoma business |
| Zdroj: | Actas Dermo-Sifiliográficas (English Edition). 108:894-901 |
| ISSN: | 1578-2190 |
| DOI: | 10.1016/j.adengl.2017.10.002 |
| Popis: | The identification of B-Raf proto-oncongene ( BRAF ) mutation and the emergence of targeted therapy marked a turning point in the treatment of melanoma. The study of mutation status concordance between primary tumors and metastases in this cancer has major treatment implications as it facilitates the selection of candidates for targeted therapy. This review analyzes the evidence on the level of mutation status concordance between primary tumors and different types of metastases in cutaneous melanoma and provides an overview of the advantages and disadvantages of the various methods used to detect BRAF mutations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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