Tissue-Specific Ultra-Short Telomeres in Chronic Obstructive Pulmonary Disease
| Autor: | Huseyin Cagsin, Ali Uzan, Ozgur Tosun, Finn Rasmussen, Nedime Serakinci |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
COPD Predictive marker medicine.diagnostic_test business.industry General Medicine medicine.disease Gastroenterology Obstructive lung disease respiratory tract diseases Telomere 03 medical and health sciences 0302 clinical medicine Bronchoalveolar lavage 030228 respiratory system Internal medicine Statistical significance medicine Tissue specific 030212 general & internal medicine Stage (cooking) business |
| Zdroj: | International Journal of Chronic Obstructive Pulmonary Disease. 15:2751-2757 |
| ISSN: | 1178-2005 |
| DOI: | 10.2147/copd.s267799 |
| Popis: | Purpose Telomere biology, especially tissue-specific ultra-short telomeres, might provide a strong contribution to our current knowledge in COPD development as well as a predictive marker for prognosis. To test this hypothesis, we investigated telomere lengths in lung tissue and leukocytes in patients diagnosed with COPD. Patients and Methods Thirty-two patients were included in the current study. All patients showed a post-bronchodilator ratio of less than 70% post-bronchodilator predicted value of forced expiratory volume in second (FEV1%), mean 56%; range [19% to 86%]. To be able to investigate ultra-short telomeres, universal single telomere length analysis (U-STELA) was used. Results Our results showed a higher level of the ultra-short telomere presence in bronchoalveolar lavage (BAL) cells when compared to leukocytes with statistical significance t(62)=5.771, p |
| Databáze: | OpenAIRE |
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