Synthesis and characterization of Fe3O4-MPTMS-PLGA nanocomposites for anticancer drug loading and release studies
| Autor: | Ayşe Karakeçili, Nuray Yıldız, Nihal Aydogan, Ayla Çalimli, Ceren Atila Dinçer |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
Nanocomposite Biomedical Engineering Pharmaceutical Science Medicine (miscellaneous) 02 engineering and technology General Medicine 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences High-performance liquid chromatography Anticancer drug 0104 chemical sciences chemistry.chemical_compound PLGA chemistry Paclitaxel Bromide Transmission electron microscopy Organic chemistry Particle size 0210 nano-technology Biotechnology Nuclear chemistry |
| Zdroj: | Artificial Cells, Nanomedicine, and Biotechnology. 45:1408-1414 |
| ISSN: | 2169-141X 2169-1401 |
| Popis: | Magnetic nanocomposites (Fe3O4-MPTMS-PLGA) were synthesized by single oil emulsion method and characterized by transmission electron microscopy (TEM), X-Ray diffraction (XRD), and vibrating sample magnetometer (VSM). Particle size of nanocomposites was between 117 nm and 246 nm. High performance liquid chromatography (HPLC) was used to investigate drug loading (paclitaxel, PTX) and release from Fe3O4-MPTMS-PLGA-PTX nanocomposites. The percentages of drug loading and encapsulation efficiency onto nanocomposites were found as 7.35 and 68.58, respectively. Cytotoxities of free anticancer drug and anticancer drug-loaded nanocomposites were determined by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. In vitro cell culture studies indicated that Fe3O4-MPTMS-PLGA-PTX had significant toxicity on MG-63 cancer cells. |
| Databáze: | OpenAIRE |
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